CD40 signaling restricts RNA virus replication in macrophages, leading to rapid innate immune control of acute virus infection

Many acute viral infections target tissue macrophages, yet the mechanisms of macrophage-mediated control of viruses are poorly understood. Here, we report that CD40 expressed by peritoneal macrophages restricts early infection of a broad range of RNA viruses. Loss of CD40 expression enhanced virus r...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Rogers, Kai J., Shtanko, Olena, Stunz, Laura L., Mallinger, Laura N., Arkee, Tina, Schmidt, Megan E., Bohan, Dana, Brunton, Bethany, White, Judith M., Varga, Steve M., Butler, Noah S., Bishop, Gail A., Maury, Wendy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774454/
https://ncbi.nlm.nih.gov/pubmed/32441445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.4HI0420-285RR
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