Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer’s Disease

Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcri...

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Bibliografski detalji
Izdano u:Front Neurosci
Glavni autori: Yin, Wencheng, Cerda-Hernández, Navei, Castillo-Morales, Atahualpa, Ruiz-Tejada-Segura, Mayra L., Monzón-Sandoval, Jimena, Moreno-Castilla, Perla, Pérez-Ortega, Rodrigo, Bermudez-Rattoni, Federico, Urrutia, Araxi O., Gutiérrez, Humberto
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774037/
https://ncbi.nlm.nih.gov/pubmed/33390887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.602642
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