Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis

Here we report a vertically integrated in vitro - in silico study that aims to elucidate the molecular initiating events involved in the induction of oxidative stress (OS) by seven diverse chemicals (cumene hydroperoxide, t-butyl hydroperoxide, hydroquinone, t-butyl hydroquinone, bisphenol A, Dinose...

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Publicat a:Chem Res Toxicol
Autors principals: Melnikov, Fjodor, Botta, Dianne, White, Collin C., Schmuck, Stefanie C., Winfough, Matthew, Schaupp, Christopher M., Gallagher, Evan P., Brooks, Bryan W., Williams, Edward Spencer, Coish, Philip, Anastas, Paul T., Voutchkova-Kostal, Adelina, Kostal, Jakub, Kavanagh, Terrance J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773541/
https://ncbi.nlm.nih.gov/pubmed/30547568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00259
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