The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects

Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with increased expression of MMPs, and therefore, they...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Broekaart, Diede W.M., Bertran, Alexandra, Jia, Shaobo, Korotkov, Anatoly, Senkov, Oleg, Bongaarts, Anika, Mills, James D., Anink, Jasper J., Seco, Jesús, Baayen, Johannes C., Idema, Sander, Chabrol, Elodie, Becker, Albert J., Wadman, Wytse J., Tarragó, Teresa, Gorter, Jan A., Aronica, Eleonora, Prades, Roger, Dityatev, Alexander, van Vliet, Erwin A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773344/
https://ncbi.nlm.nih.gov/pubmed/33141761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138332
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