Accumulation of Cerebrospinal Fluid Glycerophospholipids and Sphingolipids in Cognitively Healthy Participants With Alzheimer’s Biomarkers Precedes Lipolysis in the Dementia Stage

Insight into lipids’ roles in Alzheimer’s disease (AD) pathophysiology is limited because brain membrane lipids have not been characterized in cognitively healthy (CH) individuals. Since age is a significant risk factor of AD, we hypothesize that aging renders the amyloid precursor protein (APP) mor...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Fonteh, Alfred N., Chiang, Abby J., Arakaki, Xianghong, Edminster, Sarah P., Harrington, Michael G
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772205/
https://ncbi.nlm.nih.gov/pubmed/33390893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.611393
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