Accumulation of Cerebrospinal Fluid Glycerophospholipids and Sphingolipids in Cognitively Healthy Participants With Alzheimer’s Biomarkers Precedes Lipolysis in the Dementia Stage

Insight into lipids’ roles in Alzheimer’s disease (AD) pathophysiology is limited because brain membrane lipids have not been characterized in cognitively healthy (CH) individuals. Since age is a significant risk factor of AD, we hypothesize that aging renders the amyloid precursor protein (APP) mor...

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Foilsithe in:Front Neurosci
Main Authors: Fonteh, Alfred N., Chiang, Abby J., Arakaki, Xianghong, Edminster, Sarah P., Harrington, Michael G
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772205/
https://ncbi.nlm.nih.gov/pubmed/33390893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.611393
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