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Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions

Extracellular HMGB1 acts as an alarmin in multiple autoimmune diseases. While its release and functions have been extensively studied, there is a substantial lack of knowledge regarding HMGB1 regulation at the site of inflammation. Herein we show that enzymes present in arthritis-affected joints pro...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Sowinska, Agnieszka, Rensing, Merlin, Klevenvall, Lena, Neog, Manoj, Lundbäck, Peter, Harris, Helena Erlandsson
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772184/
https://ncbi.nlm.nih.gov/pubmed/33391251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.448262
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