A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: phenotype and impact on adrenocortical function

Phosphodiesterases catalyze the hydrolysis of cyclic nucleotides and maintain physiologic levels of intracellular concentrations of cyclic adenosine and guanosine mono-phosphate (cAMP and cGMP, respectively). Increased cAMP signaling has been associated with adrenocortical tumors and Cushing syndrom...

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Gepubliceerd in:Mol Cell Endocrinol
Hoofdauteurs: Levy, Isaac, Szarek, Eva, Maria, Andrea Gutierrez, Starrost, Matthew, De La Luz Sierra, Maria, Faucz, Fabio R., Stratakis, Constantine A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7771190/
https://ncbi.nlm.nih.gov/pubmed/33127481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2020.111071
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