Gamete binning: chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes

Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whole-genome sequencing reads into haplotype-specific reads set...

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Vydáno v:Genome Biol
Hlavní autoři: Campoy, José A., Sun, Hequan, Goel, Manish, Jiao, Wen-Biao, Folz-Donahue, Kat, Wang, Nan, Rubio, Manuel, Liu, Chang, Kukat, Christian, Ruiz, David, Huettel, Bruno, Schneeberger, Korbinian
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7771071/
https://ncbi.nlm.nih.gov/pubmed/33372615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02235-5
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