Advanced glycation end products cause RAGE‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models

Aging and diabetes are associated with increased low‐back pain and intervertebral disk (IVD) degeneration yet causal mechanisms remain uncertain. Advanced glycation end products (AGEs), which accumulate in IVDs from aging and are implicated in diabetes‐related disorders, alter collagen and induce pr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JOR Spine
Egile Nagusiak: Hoy, Robert C., D'Erminio, Danielle N., Krishnamoorthy, Divya, Natelson, Devorah M., Laudier, Damien M., Illien‐Jünger, Svenja, Iatridis, James C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Inc. 2020
Gaiak:
Special Issue PSRS Conference 2019
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770195/
https://ncbi.nlm.nih.gov/pubmed/33392460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jsp2.1126
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