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Local cortical overexpression of human wild-type alpha-synuclein leads to increased dendritic spine density in mouse.

Lewy body dementias are characterized by deposition of alpha-synuclein (α-syn) protein aggregates known as Lewy bodies and Lewy neurites in cortical regions, in addition to brainstem. These aggregates are thought to cause the death of dopaminergic neurons in the substantia nigra and other vulnerable...

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Publicat a:Neurosci Lett
Autors principals: Wagner, L.M., Nathwani, S.M., Ten Eyck, P.P., Aldridge, G.M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769708/
https://ncbi.nlm.nih.gov/pubmed/32417387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135051
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