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Local cortical overexpression of human wild-type alpha-synuclein leads to increased dendritic spine density in mouse.

Lewy body dementias are characterized by deposition of alpha-synuclein (α-syn) protein aggregates known as Lewy bodies and Lewy neurites in cortical regions, in addition to brainstem. These aggregates are thought to cause the death of dopaminergic neurons in the substantia nigra and other vulnerable...

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Pubblicato in:Neurosci Lett
Autori principali: Wagner, L.M., Nathwani, S.M., Ten Eyck, P.P., Aldridge, G.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769708/
https://ncbi.nlm.nih.gov/pubmed/32417387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135051
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