Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier

Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. The...

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Опубликовано в: :PLoS Biol
Главные авторы: Gallego-Delgado, Patricia, James, Rachel, Browne, Eleanor, Meng, Joanna, Umashankar, Swetha, Tan, Li, Picon, Carmen, Mazarakis, Nicholas D., Faisal, A. Aldo, Howell, Owain W., Reynolds, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769608/
https://ncbi.nlm.nih.gov/pubmed/33315860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001008
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