Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing

Deletions and duplications in mitochondrial DNA (mtDNA) cause mitochondrial disease and accumulate in conditions such as cancer and age-related disorders, but validated high-throughput methodology that can readily detect and discriminate between these two types of events is lacking. Here we establis...

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Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Basu, Swaraj, Xie, Xie, Uhler, Jay P., Hedberg-Oldfors, Carola, Milenkovic, Dusanka, Baris, Olivier R., Kimoloi, Sammy, Matic, Stanka, Stewart, James B., Larsson, Nils-Göran, Wiesner, Rudolf J., Oldfors, Anders, Gustafsson, Claes M., Falkenberg, Maria, Larsson, Erik
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769605/
https://ncbi.nlm.nih.gov/pubmed/33315859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009242
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