Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons

The mechanisms by which prenatal immune activation increase risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs), known to be affected in schizophrenia (SCZ) when matured, from induced pluripotent stem cells (iPSCs) from healthy controls (HC)...

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Veröffentlicht in:Nat Neurosci
Hauptverfasser: Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769122/
https://ncbi.nlm.nih.gov/pubmed/33097921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-00724-1
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