Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency

The design of modified oligonucleotides that combine in one molecule several therapeutically beneficial properties still poses a major challenge. Recently a new type of modified mesyl phosphoramidate (or µ-) oligonucleotide was described that demonstrates high affinity to RNA, exceptional nuclease r...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Patutina, Olga A., Gaponova (Miroshnichenko), Svetlana K., Sen’kova, Aleksandra V., Savin, Innokenty A., Gladkikh, Daniil V., Burakova, Ekaterine A., Fokina, Alesya A., Maslov, Mikhail A., Shmendel’, Elena V., Wood, Mattew J. A., Vlassov, Valentin V., Altman, Sidney, Stetsenko, Dmitry A., Zenkova, Marina A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768764/
https://ncbi.nlm.nih.gov/pubmed/33288723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016158117
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