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Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease

Preclinical and clinical data support the use of focused ultrasound (FUS), in the presence of intravenously injected microbubbles, to safely and transiently increase the permeability of the blood–brain barrier (BBB). FUS-induced BBB permeability has been shown to enhance the bioavailability of admin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dubey, Sonam, Heinen, Stefan, Krantic, Slavica, McLaurin, JoAnne, Branch, Donald R., Hynynen, Kullervo, Aubert, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768694/
https://ncbi.nlm.nih.gov/pubmed/33288687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908658117
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