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The shape of gene expression distributions matter: how incorporating distribution shape improves the interpretation of cancer transcriptomic data

BACKGROUND: In genomics, we often assume that continuous data, such as gene expression, follow a specific kind of distribution. However we rarely stop to question the validity of this assumption, or consider how broadly applicable it may be to all genes that are in the transcriptome. Our study inves...

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書誌詳細
出版年:BMC Bioinformatics
主要な著者: de Torrenté, Laurence, Zimmerman, Samuel, Suzuki, Masako, Christopeit, Maximilian, Greally, John M., Mar, Jessica C.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768656/
https://ncbi.nlm.nih.gov/pubmed/33371881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-03892-w
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