Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare neurodegenerative disorder caused by a 55–200 CGG repeat expansion in the 5′ untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene. FXTAS is characterized by progressive cerebellar ataxia, Parkinsonism, intention tremors a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Mol Biosci
Autori principali: Haify, Saif N., Mankoe, Ruchira S. D., Boumeester, Valerie, van der Toorn, Esmay C., Verhagen, Rob F. M., Willemsen, Rob, Hukema, Renate K., Bosman, Laurens W. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Molecular Biosciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768028/
https://ncbi.nlm.nih.gov/pubmed/33381520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.599101
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi