MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β(1)-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the tar...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Zondler, Lisa, Herich, Sebastian, Kotte, Petra, Körner, Katharina, Schneider-Hohendorf, Tilman, Wiendl, Heinz, Schwab, Nicholas, Zarbock, Alexander
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767877/
https://ncbi.nlm.nih.gov/pubmed/33381120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.599936
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