MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β(1)-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the tar...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zondler, Lisa, Herich, Sebastian, Kotte, Petra, Körner, Katharina, Schneider-Hohendorf, Tilman, Wiendl, Heinz, Schwab, Nicholas, Zarbock, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767877/
https://ncbi.nlm.nih.gov/pubmed/33381120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.599936
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