VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells

The focus of this study is the characterization of human T cell blood–brain barrier migration and corresponding molecular trafficking signatures. We examined peripheral blood and cerebrospinal fluid immune cells from patients under long-term anti–very late antigen-4 (VLA-4)/natalizumab therapy (LTNT...

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Autors principals: Schneider-Hohendorf, Tilman, Rossaint, Jan, Mohan, Hema, Böning, Daniel, Breuer, Johanna, Kuhlmann, Tanja, Gross, Catharina C., Flanagan, Ken, Sorokin, Lydia, Vestweber, Dietmar, Zarbock, Alexander, Schwab, Nicholas, Wiendl, Heinz
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144733/
https://ncbi.nlm.nih.gov/pubmed/25135296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140540
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