Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes

Stargardt macular degeneration (STGD) is a central blinding disease caused by loss of or dysfunctional ABCA4 transporter in both photoreceptors and retinal pigment epithelial (RPE) cells. Toxic bisretinoid-lipofuscin buildup in the RPE cells is a pathological hallmark of STGD patients and its mouse...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Hu, Jane, Pauer, Gayle J., Hagstrom, Stephanie A., Bok, Dean, DeBenedictis, Meghan J., Bonilha, Vera L., Hollyfield, Joe G., Radu, Roxana A.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767765/
https://ncbi.nlm.nih.gov/pubmed/33214125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101787
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