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Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4
Thymine:guanine base pairs are major promutagenic mismatches occurring in DNA metabolism. If left unrepaired, these mispairs can cause C to T transition mutations. In humans, T:G mismatches are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-binding domain 4 (hMBD4) and thy...
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| Publicat a: | Biochem J |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7767623/ https://ncbi.nlm.nih.gov/pubmed/32297632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200125 |
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