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Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4

Thymine:guanine base pairs are major promutagenic mismatches occurring in DNA metabolism. If left unrepaired, these mispairs can cause C to T transition mutations. In humans, T:G mismatches are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-binding domain 4 (hMBD4) and thy...

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Bibliografiske detaljer
Udgivet i:Biochem J
Main Authors: Ouzon-Shubeita, Hala, Jung, Hunmin, Lee, Michelle H., Koag, Myong-Chul, Lee, Seongmin
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767623/
https://ncbi.nlm.nih.gov/pubmed/32297632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200125
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