Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

Exogenously administered 17β-estradiol (E2) can improve spatial learning and memory, although E2 also exerts undesired effects on peripheral organs. Clinically, E2 has been solubilized in cyclodextrin for intranasal administration, which enhances brain-specific delivery. Prior work shows that the cy...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Prakapenka, Alesia V., Peña, Veronica L., Strouse, Isabel, Northup-Smith, Steven, Schrier, Ally, Ahmed, Kinza, Bimonte-Nelson, Heather A., Sirianni, Rachael W.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766209/
https://ncbi.nlm.nih.gov/pubmed/33348722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12121225
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