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Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: Evidence that the duration of hormone deprivation after ovariectomy compromises 17β-estradiol effectiveness in altering CA1 spines

Two pulses of 17β-estradiol (10µg) are commonly used to increase hippocampal CA1 apical dendritic spine density and alter spatial performance in ovariectomized (OVX) female rats, but rarely are the measures combined. The goal of this study was to use this two-pulse injection protocol repeatedly with...

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Detalhes bibliográficos
Main Authors: McLaughlin, Katie J., Bimonte-Nelson, Heather, Neisewander, Janet L., Conrad, Cheryl D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602955/
https://ncbi.nlm.nih.gov/pubmed/18579142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yhbeh.2008.04.010
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