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APC Mutations Are Not Confined to Hotspot Regions in Early-Onset Colorectal Cancer

SIMPLE SUMMARY: Mutation of the APC gene is a common early event in colorectal cancer, however lower rates have been reported in younger cohorts of colorectal cancer patients. In sporadic cancer, mutations are typically clustered around a mutation cluster region, a narrowly defined hotspot within th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Aitchison, Alan, Hakkaart, Christopher, Day, Robert C., Morrin, Helen R., Frizelle, Frank A., Keenan, Jacqueline I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766084/
https://ncbi.nlm.nih.gov/pubmed/33352971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123829
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