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APC mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by screening the whole gene for mutations and assessing allelic loss. APC seems to act as a tumor-suppressor gene in a “nonclassical” fashion: data from familial adenomatous po...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16243/ https://ncbi.nlm.nih.gov/pubmed/10737795 |
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