APC mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”

Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by screening the whole gene for mutations and assessing allelic loss. APC seems to act as a tumor-suppressor gene in a “nonclassical” fashion: data from familial adenomatous po...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rowan, A. J., Lamlum, H., Ilyas, M., Wheeler, J., Straub, J., Papadopoulou, A., Bicknell, D., Bodmer, W. F., Tomlinson, I. P. M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10737795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.7.3352
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