A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inh...

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Detalhes bibliográficos
Publicado no:Nat Nanotechnol
Main Authors: Ramírez-García, Paulina D., Retamal, Jeffri S., Shenoy, Priyank, Imlach, Wendy, Sykes, Matthew, Truong, Nghia, Constandil, Luis, Pelissier, Teresa, Nowell, Cameron J., Khor, Song Y., Layani, Louis M., Lumb, Chris, Poole, Daniel P., Lieu, TinaMarie, Stewart, Gregory D., Mai, Quynh N., Jensen, Dane D., Latorre, Rocco, Scheff, Nicole N., Schmidt, Brian L., Quinn, John F., Whittaker, Michael R., Veldhuis, Nicholas A., Davis, Thomas P., Bunnett, Nigel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7765343/
https://ncbi.nlm.nih.gov/pubmed/31686009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-019-0568-x
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