Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection

The mechanism of H. pylori-induced atrophy and metaplasia has not been fully understood. Here, we demonstrate the novel role of Apoptosis signal-regulating kinase 1 (ASK1) and downstream MAPKs as a regulator of host immune responses and epithelial maintenance against H. pylori infection. ASK1 gene d...

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Publicat a:Microorganisms
Autors principals: Hayakawa, Yoku, Hirata, Yoshihiro, Hata, Masahiro, Tsuboi, Mayo, Oya, Yukiko, Kurokawa, Ken, Abe, Sohei, Arai, Junya, Suzuki, Nobumi, Nakagawa, Hayato, Fujiwara, Hiroaki, Tateishi, Keisuke, Maeda, Shin, Koike, Kazuhiko
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7765114/
https://ncbi.nlm.nih.gov/pubmed/33542169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8121995
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