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Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature

BACKGROUND: The blood‐brain barrier (BBB) is critical for cerebrovascular health. Although aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not clear. As mitochondrial components activate inflammation as mitochondria become dysfunctional, we examined how aging impact...

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Pubblicato in:J Am Heart Assoc
Autori principali: Tyrrell, Daniel J., Blin, Muriel G., Song, Jianrui, Wood, Sherri C., Goldstein, Daniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763766/
https://ncbi.nlm.nih.gov/pubmed/33225820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.017820
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