Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature

BACKGROUND: The blood‐brain barrier (BBB) is critical for cerebrovascular health. Although aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not clear. As mitochondrial components activate inflammation as mitochondria become dysfunctional, we examined how aging impact...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Tyrrell, Daniel J., Blin, Muriel G., Song, Jianrui, Wood, Sherri C., Goldstein, Daniel R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763766/
https://ncbi.nlm.nih.gov/pubmed/33225820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.017820
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