Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

BACKGROUND: To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic and phenotypic analyses of patient‐ and healthy...

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Pubblicato in:J Am Heart Assoc
Autori principali: Lam, Yin‐Yu, Keung, Wendy, Chan, Chun‐Ho, Geng, Lin, Wong, Nicodemus, Brenière‐Letuffe, David, Li, Ronald A., Cheung, Yiu‐Fai
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763394/
https://ncbi.nlm.nih.gov/pubmed/33059525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.016528
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