Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

BACKGROUND: To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic and phenotypic analyses of patient‐ and healthy...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Am Heart Assoc
Κύριοι συγγραφείς: Lam, Yin‐Yu, Keung, Wendy, Chan, Chun‐Ho, Geng, Lin, Wong, Nicodemus, Brenière‐Letuffe, David, Li, Ronald A., Cheung, Yiu‐Fai
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2020
Θέματα:
Original Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763394/
https://ncbi.nlm.nih.gov/pubmed/33059525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.016528
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