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AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and γ. AMPKα and β are encoded by two genes, the γ subunit by three genes, all of which are expressed in a...

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Vydáno v:J Biol Chem
Hlavní autoři: Ziegler, Nicole, Bader, Erik, Epanchintsev, Alexey, Margerie, Daniel, Kannt, Aimo, Schmoll, Dieter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762962/
https://ncbi.nlm.nih.gov/pubmed/33454005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013990
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