Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition

Erythromycin-resistance methyltransferases are SAM dependent Rossmann fold methyltransferases that convert A2058 of 23S rRNA to m(6) (2)A2058. This modification sterically blocks binding of several classes of antibiotics to 23S rRNA, resulting in a multidrug-resistant phenotype in bacteria expressin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rowe, Sebastian J., Mecaskey, Ryan J., Nasef, Mohamed, Talton, Rachel C., Sharkey, Rory E., Halliday, Joshua C., Dunkle, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762948/
https://ncbi.nlm.nih.gov/pubmed/33453992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014280
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