Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition

Erythromycin-resistance methyltransferases are SAM dependent Rossmann fold methyltransferases that convert A2058 of 23S rRNA to m(6) (2)A2058. This modification sterically blocks binding of several classes of antibiotics to 23S rRNA, resulting in a multidrug-resistant phenotype in bacteria expressin...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Rowe, Sebastian J., Mecaskey, Ryan J., Nasef, Mohamed, Talton, Rachel C., Sharkey, Rory E., Halliday, Joshua C., Dunkle, Jack A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762948/
https://ncbi.nlm.nih.gov/pubmed/33453992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014280
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