Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation

Chromosomal translocations are prevalent among soft tissue tumors, including those of the vasculature such as pseudomyogenic hemangioendothelioma (PHE). PHE shows endothelial cell (EC) features and has a tumor-specific t(7;19)(q22;q13) SERPINE1-FOSB translocation, but is difficult to study as no pri...

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Veröffentlicht in:Cell Rep Med
Hauptverfasser: van IJzendoorn, David G.P., Salvatori, Daniela C.F., Cao, Xu, van den Hil, Francijna, Briaire-de Bruijn, Inge H., de Jong, Danielle, Mei, Hailiang, Mummery, Christine L., Szuhai, Karoly, Bovée, Judith V.M.G., Orlova, Valeria V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762773/
https://ncbi.nlm.nih.gov/pubmed/33377124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100153
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