E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc

FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment....

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Zhong, Lijia, Zhang, Yuanyuan, Li, Mengyao, Song, Yinjing, Liu, Danhui, Yang, Xin, Yang, Dehua, Qu, Hao, Lai, Lihua, Wang, Qingqing, Chen, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762499/
https://ncbi.nlm.nih.gov/pubmed/33260160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202293
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