Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways

The role of oxidative stress in ligamentum flavum (LF) hypertrophy has not been elucidated. We hypothesize that oxidative stress induces inflammatory responses and the subsequent fibrotic processes in LF, via activation of the Akt and MAPK pathways. Specimens of LFs were collected during surgeries f...

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Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Chuang, Hao-Chun, Tsai, Kun-Ling, Tsai, Kuen-Jer, Tu, Ting-Yuan, Shyong, Yan-Jye, Jou, I-Ming, Hsu, Che-Chia, Shih, Shu-Shien, Liu, Yuan-Fu, Lin, Cheng-Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762458/
https://ncbi.nlm.nih.gov/pubmed/33223505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104105
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