Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways

The role of oxidative stress in ligamentum flavum (LF) hypertrophy has not been elucidated. We hypothesize that oxidative stress induces inflammatory responses and the subsequent fibrotic processes in LF, via activation of the Akt and MAPK pathways. Specimens of LFs were collected during surgeries f...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chuang, Hao-Chun, Tsai, Kun-Ling, Tsai, Kuen-Jer, Tu, Ting-Yuan, Shyong, Yan-Jye, Jou, I-Ming, Hsu, Che-Chia, Shih, Shu-Shien, Liu, Yuan-Fu, Lin, Cheng-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762458/
https://ncbi.nlm.nih.gov/pubmed/33223505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104105
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