Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways

The role of oxidative stress in ligamentum flavum (LF) hypertrophy has not been elucidated. We hypothesize that oxidative stress induces inflammatory responses and the subsequent fibrotic processes in LF, via activation of the Akt and MAPK pathways. Specimens of LFs were collected during surgeries f...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Chuang, Hao-Chun, Tsai, Kun-Ling, Tsai, Kuen-Jer, Tu, Ting-Yuan, Shyong, Yan-Jye, Jou, I-Ming, Hsu, Che-Chia, Shih, Shu-Shien, Liu, Yuan-Fu, Lin, Cheng-Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762458/
https://ncbi.nlm.nih.gov/pubmed/33223505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104105
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