Unraveling the Resistance of IGF-Pathway Inhibition in Ewing Sarcoma

SIMPLE SUMMARY: The insulin-like growth factor-1 receptor (IGF1R) is a receptor commonly overexpressed and overactivated in a variety of cancers, including Ewing sarcoma, and promotes cell growth and survival. After promising results with targeting and inhibiting the receptor in vitro, multiple diff...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: de Groot, Stefanie, Röttgering, Bas, Gelderblom, Hans, Pijl, Hanno, Szuhai, Karoly, Kroep, Judith R.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759976/
https://ncbi.nlm.nih.gov/pubmed/33260481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123568
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