Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

HIV/SIV persistence in latent reservoirs requires lifelong antiretroviral treatment and calls for effective cure strategies. Romidepsin (RMD), a histone deacetylase inhibitor, was reported to reactivate HIV/SIV from reservoirs in virus-suppressed individuals. We characterized in detail the pharmacok...

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Udgivet i:Front Immunol
Main Authors: Kleinman, Adam J., Xu, Cuiling, Cottrell, Mackenzie L., Sivanandham, Ranjit, Brocca-Cofano, Egidio, Dunsmore, Tammy, Kashuba, Angela, Pandrea, Ivona, Apetrei, Cristian
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759686/
https://ncbi.nlm.nih.gov/pubmed/33362765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.579158
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