Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

In relapsed and refractory multiple myeloma (MM), adoptive cell therapies (ACT) including CAR-T-cells are under clinical investigation. However, relapse due to T-cell exhaustion or limited persistence is an obstacle. Before ACT are considered in MM, high-dose (HD) melphalan followed by autologous st...

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Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Mika, Thomas, Ladigan-Badura, Swetlana, Maghnouj, Abdelouahid, Mustafa, Bakr, Klein-Scory, Susanne, Baraniskin, Alexander, Döhring, Sascha, Fuchs, Ilka, Ehl, Stephan, Hahn, Stephan A., Schroers, Roland
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759611/
https://ncbi.nlm.nih.gov/pubmed/33363008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.568056
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