HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific antiviral effectors. Here, we show that both par...

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Veröffentlicht in:eLife
Hauptverfasser: Khan, Hataf, Sumner, Rebecca P, Rasaiyaah, Jane, Tan, Choon Ping, Rodriguez-Plata, Maria Teresa, Van Tulleken, Chris, Fink, Douglas, Zuliani-Alvarez, Lorena, Thorne, Lucy, Stirling, David, Milne, Richard SB, Towers, Greg J
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Microbiology and Infectious Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759385/
https://ncbi.nlm.nih.gov/pubmed/33300875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60821
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