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Chronic Methadone Use Alters the CD8+ T Cell Phenotype In Vivo and Modulates Its Responsiveness Ex Vivo to Opioid Receptor and TCR Stimuli
Endogenous opioid peptides are released at sites of injury, and their cognate G protein–coupled opioid receptors (ORs) are expressed on immune cells. Although drugs of misuse appropriate ORs, conflicting reports indicate immunostimulatory and immunosuppressive activity, in that opioid users have ele...
Gardado en:
| Publicado en: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7757720/ https://ncbi.nlm.nih.gov/pubmed/31969385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900862 |
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