IGFBP7 activates retinoid acid–induced responses in acute myeloid leukemia stem and progenitor cells

Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) in combination with low doses of arsenic trioxide or chemotherapy leads to exceptionally high cure rates (>90%). ATRA forces APL cells into differentiation and cell death. Unfortunately, ATRA-based therapy has not...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: van Gils, Noortje, Verhagen, Han J. M. P., Rutten, Arjo, Menezes, Renee X., Tsui, Mei-Ling, Vermue, Eline, Dekens, Esmée, Brocco, Fabio, Denkers, Fedor, Kessler, Floortje L., Ossenkoppele, Gert J., Janssen, Jeroen J. W. M., Smit, Linda
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756998/
https://ncbi.nlm.nih.gov/pubmed/33351133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002812
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