Food‐Poisoning Bacteria Employ a Citrate Synthase and a Type II NRPS To Synthesize Bolaamphiphilic Lipopeptide Antibiotics

Mining the genome of the food‐spoiling bacterium Burkholderia gladioli pv. cocovenenans revealed five nonribosomal peptide synthetase (NRPS) gene clusters, including an orphan gene locus (bol). Gene inactivation and metabolic profiling linked the bol gene cluster to novel bolaamphiphilic lipopeptide...

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Foilsithe in:Angew Chem Int Ed Engl
Main Authors: Dose, Benjamin, Ross, Claudia, Niehs, Sarah P., Scherlach, Kirstin, Bauer, Johanna P., Hertweck, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
Ábhair:
Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756705/
https://ncbi.nlm.nih.gov/pubmed/32780428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202009107
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