Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein

The accumulation of amyloid-β (Aβ) is a characteristic event in the pathogenesis of Alzheimer’s disease (AD). Aquaporin 1 (AQP1) is a membrane water channel protein belonging to the AQP family. AQP1 levels are elevated in the cerebral cortex during the early stages of AD, but the role of AQP1 in AD...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Gerontol A Biol Sci Med Sci
Main Authors: Park, Jinsu, Madan, Meenu, Chigurupati, Srinivasulu, Baek, Seung Hyun, Cho, Yoonsuk, Mughal, Mohamed R, Yu, Amin, Chan, Sic L, Pattisapu, Jogi V, Mattson, Mark P, Jo, Dong-Gyu
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2020
נושאים:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756701/
https://ncbi.nlm.nih.gov/pubmed/32154567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glaa068
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