Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates

Two Burkholderia gladioli strains isolated from the lungs of cystic fibrosis patients were found to produce unusual lipodepsipeptides containing a unique citrate‐derived fatty acid and a rare dehydro‐β‐alanine residue. The gene cluster responsible for their biosynthesis was identified by bioinformat...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Dashti, Yousef, Nakou, Ioanna T., Mullins, Alex J., Webster, Gordon, Jian, Xinyun, Mahenthiralingam, Eshwar, Challis, Gregory L.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756342/
https://ncbi.nlm.nih.gov/pubmed/32780452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202009110
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