An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azoffluxin) that synergizes with fluconazole against C....

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755909/
https://ncbi.nlm.nih.gov/pubmed/33353950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20183-3
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